A nonsense mutation of bone morphogenetic protein-15 (BMP15) causes both infertility and increased litter size in pigs
نویسندگان
چکیده
منابع مشابه
polymorphism of exon 2 of bone morphogenetic protein 15 gene (bmp15) and its relationship with litter size in najdi goat
this study was conducted to detect polymorphism of gene bmp15, a member of transforming growthfactor β (tgfβ) family which has a crucial role in controlling the ovarian follicles development,ovulation rate and fertility. samples were randomly selected from 91 najdi goats in 3 geographicallocations, northwest, southeast and center of khuzestan province. after dna extraction, amplification of235 ...
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Bone morphogenetic protein 15 (BMP15) belongs to an unusual subgroup of the transforming growth factor beta (TGFbeta) superfamily of signaling ligands as it lacks a key cysteine residue in the mature region required for proper intermolecular dimerization. Naturally occurring BMP15 mutation leads to early ovarian failure in humans, and BMP15 has been shown to activate the Smad1/5/8 pathway in th...
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Partial neutralization of bone morphogenetic protein 15 (BMP15) bioactivity by immunization is known to increase ovulation rate in sheep. However, it remains uncertain whether BMP15 vaccination would be a suitable procedure for increasing lambing rate. The aim of this study was to compare the efficacy of a BMP15 vaccination treatment on lamb production to that of commercially-available androste...
متن کاملA deletion in the bone morphogenetic protein 15 gene causes sterility and increased prolificacy in Rasa Aragonesa sheep.
Bone morphogenetic protein 15 (BMP15) is a member of the transforming growth factor beta superfamily, is specifically expressed in oocytes and is essential for sheep prolificacy. Reported mutations in this gene cause increased ovulation rate and infertility in a dosage-sensitive manner. In this work, a new naturally occurring mutation in the BMP15 gene from the ovine Rasa Aragonesa breed is des...
متن کاملmutation analysis of exon1 of bone morphogenetic protein-15 gene in iranian patients with polycystic ovarian syndrome
background: with the prevalence of 6-10%, polycystic ovarian syndrome (pcos) is considered the most common endocrinological disorder affecting women in their reproductive age. it has been suggested that genetic factors participate in the development of pcos. follicular development has been considered as one of the impaired processes in pcos. bone morphogenetic protein-15 (bmp-15) gene is a cand...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2021
ISSN: 1471-2164
DOI: 10.1186/s12864-020-07343-x